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Technical Report on Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
P.C. Chan (ed)
Cumene is produced in a modified Friedel-Crafts reaction process. Cumene is the principal chemical used in the production of phenol and acetone. Cumene is used: as a thinner; as a constituent of some petroleum-based solvents; in gasoline blending, diesel fuel, and high-octane aviation fuel; and as a raw material for peroxides and oxidation catalysts. Because cumene is a good solvent for fats and resins, it has been suggested as a replacement for benzene in many industrial applications. Cumene occurs naturally in petroleum and in a variety of foodstuffs. Cumene was nominated for study because of its high production volume, presence in gasoline and other fuels, potential for human exposure, and lack of existing carcinogenecity test data. Illus.
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