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Genetically Modified Model Report on the Toxicology Study of Diisopropylcarbodiimide and the Carcinogenicity Study of Diisopropylcarbodiimide
R. S. Chhhabra (ed)
Diisopropylcarbodiimide is used as a reagent for a variety of reactions including peptide syntheses. The Nat. Cancer Inst. nominated diisopropylcarbodiimide for study as a representative chemical in the alkylcarbodiimide class because of its acute toxicity, widespread low-level human exposure, & the absence of data on health effects. Female Tg.AC hemizygous or p53 haploinsufficient mice were administered diisopropylcarbodiimide (greater than 99% pure) dermally for 20 or 27 weeks, respectively. Illustrations.
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