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Genetically Modified Model Report on the Toxicology Studies of Pentaerythritol Triacrylate (PT) (Technical Grade) (CAS No. 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
R.S. Chhabra (ed); J. Mahler (ed)
PT is used in the prodín. of ultraviolet-curable inks & coatings, electron beam irradiation-curable coatings, & radiation-cured & photocurable castings of urethanes & epoxy resins, & as an ingred. in acrylic glues, polyester, fiberglass, industrial baked coatings, & polymer-impregnated concrete. It is being testing based on its high prod. vol. & use, its potential for human exposure, & a lack of adequate test. Conclusions: Male & female Tg.AC hemizygous mice had significantly increased incidences of squamous cell (SC) papillomas of the skin at the site of dermal applín. Treatment-related SC carcinomas occurred at the site of applín. in male mice. Nonneoplastic lesions noted at the site of applín. included hyperkeratosis, & chronic active inflam. Illus.
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