Join our mailing list!
(Your shopping cart is empty)
Diane Publishing Books
Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide
R. S. Chabra (ed)
Dicyclohexylcarbodiimide is used in industry as a stabilizing agent, coupling agent, & condensing agent. Its widespread use during protein synthesis in the recombinant DNA industry & in the synthesis of polypeptides in the chemical & pharmaceutical industries provides an increasing potential for low-level human exposure. Dicyclohexylcarbodiimide was nominated for study as a key representative of the carbodiimide chemical class because of its acute toxicity & the absence of data on potential health effects. Under the conditions of this 27-week dermal study, there was no evidence of carcinogenic activity of dicyclohexylcarbodiimide in female p53 haplo-insufficient mice administered 0.75, 3, 6, or 12 mg/kg in ethanol. Female Tg.AC hemizygous mice dermally dosed with dicyclohexylcarbodiimide for 20 weeks had significantly increased incidences of squamous cell papilloma of the skin at the site of application. Non-neoplastic lesions noted at the site of application included chronic active inflammation & epidermal hyperplasia in female p53 haplo-insufficient mice & female Tg.AC hemizygous mice. Illus.
Secret Agenda: One Manís Fight Against High-Tech Terrorists & Their Biological & Nuclear Weapons of Mass Destruction
Years of Renewal
Sale Price: $12.00
Essential Tibetan Buddhism
Kilims: Decorating with Tribal Rugs
Bridges of Battle: Famous Battlefield Actions at Bridges & River Crossings
Share your knowledge of this product with other customers...
Be the first to write a review
Diane Publishing Co
PO Box 617
Darby, PA 19023-0617
Become an Affiliate
Send Us Feedback
Copyright ï¿½ 2004 Diane Publishing Company. All Rights Reserved.