Includes those adult Tanypodinae ( = Pelopinae) found in the U.S. & Canada north of the Mexican border. Includes Greenland but excludes Bermuda, the Bahamas, & the West Indies; only the adults are considered here. Keys are provided for the identification of both sexes, though the prime reliance is upon the characters of the male. The classification used is essentially (with some modification) that of Fittkau (1962). A total of 130 species & 38 genera or subgenera are treated in this paper. Of these, 48 species & 11 genera or subgenera are new. Of the 17 genera of Pentaneurini treated by Fittkau (1962), only “Telmatopelopia” was not found in North America. All the genera listed by Fittkau for the Macropelopiini were found here. “Anatopynia” s. str. wasn’t found.