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Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3’,4,4’,5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) and 2,2’,4,4’,5,5’-Hexachlorobiphenyl (PCB 152) (CAS No. 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies): Technic
M.E. Wyde (ed)
Polyhalogenated aromatic hydrocarbons such as 2,3,7.8-tetrachlorodibenzo-p=-dioxin (TCDD) have the ability to bind to and activate the ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR). Structurally related compounds that bind to the AhR and exhibit biological actions similar to TCDD are commonly referred to as “dioxin-like compounds” (DLCs). Ambient human exposure to DLCs occurs through the ingestion of foods containing residues of DLCs that bioconcentrate through the food chain. The toxic equivalency of DLCs was nominated for evaluation because of the widespread human exposure to DLCs and the lack of data on the adequacy of the TEF methodology for predicting relative potency for cancer risk. To address this, the Nat. Toxicology Program conducted a series of 2-year bioassays in female Harlan Sprague-Dawley rats to evaluate the chronic toxicity and carcinogenicity of DLCs and structurally related polychlorinated biphenyls (PCBs) and mixtures of these compounds. Illus.
Around the American Table: Treasured Recipes & Food Traditions from the American Cookery Collections of the New York Public Library
Secret World of the Spy: Stories of Espionage, Deception & Discovery
Paperie: The Art of Writing & Wrapping with Paper
Politician Goes to War: The Civil War Letters of John White Geary
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