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Toxicology and Carcinogenesis Studies of Transplacental 3’-Azido-3’-deoxythymidine (AZT) (CAS No. 30516-87-1) in Swiss (CD-1) Mice (“In Utero” Studies)
3’-Azido-3’-deoxythymidine (AZT) is the most widel

Our Price: $45.00
By W.G. Lieuallen (ed)
Year: 2006
Pages: 183
Binding Paperback

Product Code: 1422307964

3’-Azido-3’-deoxythymidine (AZT) is the most widely used agent for the treatment of people with AIDS or seropositive for HIV. AZT was known to cause cancer in mice born to mothers exposed to doses of 400 mg per kg of body weight or higher during pregnancy. This  study exposed female mice to lower concentrations of AZT (50-300 mg AZT/kg body weight) before & during pregnancy to determine if those doses also caused cancer in the offspring. The study concludes that exposure of pregnant female mice to AZT resulted in increased rates of lung cancer in their male offspring. There was no difference in cancer in female offspring of mothers exposed to 300 mg AZT/kg body weight or less during pregnancy. Charts & tables.

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