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Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CAS No. 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
F.A. Suarez (ed)
Examines methyl isobutyl ketone (MIK), which is used as a solvent for paints & lacquers in dry cleaning. It was studied to determine if it caused cancer in rats or mice. Groups of 50 male & 50 female rats & mice were exposed to air containing concent. of 450, 900, or 1,800 parts/mill. (ppm) of MIK 6 hrs./day for 2 days. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers 6 hrs./day as the untreated control gorups. Tissues from 40 sites were examined for every animal. Conclusion: MIK caused cancer of the kidney in male rats & of the liver in male & female mice. Increases in mononuclear cell leukemia in male rats & mesenchymal tumors in the kidney of female rats may also have been related to exposure to MIK. Illus.
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