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Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CAS No. 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
R. L. Melnick (ed)
Dibromoacetic acid (DA), a water disinfection byproduct, was nominated for toxicity & carcinogenicity studies in rats & mice because of widespread human exposure & because a related dihaloacetate, dichloroacetate, was found to be carcinogenic to the liver of rats & mice. Drinking water was selected as the route of exposure to mimic human exposure to this chemical. Male & female F344/N rats & B6C3F1 mice were exposed to DA in drinking water for 2 weeks, 3 mo., or 2 yrs. The study concluded that DA in the drinking water caused mesothelioma in male rats & mononuclear cell leukemia in female rats, & also possibly in male rats; & that it caused liver cancer in male & female mice & lung cancer in male, & possibly also in female mice. Illustrations.
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