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Toxicology and Carcinogenesis Studies of 3,3’, 4,4’, 5-Pentachlorobiphenyl (PCB 126) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
N.J. Walker (ed)
Polyhalogenated aromatic hydrocarbons such as 2, 3, 7, 8 (TCDD) have the ability to bind to & activate the ligand-activated transcription factor, AhR. Structurally related compounds that bind to the AhR & exhibit biological actions similar to TCDD are referred to as “dioxin-like compounds” (DLCs). Ambient human exposure to DLCs occurs through the ingestion of foods that contain residues of DLCs that bio-concentrate through the food chain. Once internalized they accumulate in body tissue, resulting in lifetime human exposure. The toxic equivalency of DLCs was evaluated because of widespread human exposure to DLCs & the lack of data on the adequacy of the toxic equivalency factor methodology for predicting potency for cancer risk. Illus.
Saddam Hussein: Defying the World: A Visual Biography (video)
Woman’s Guide to Making Therapy Work
Rudy!: An Investigative Biography of Rudy Giuliani
Applique: The Ann Boyce Way
Whiz Kid of Wall Street’s Investment Guide: How I Returned 34% on My Portfolio, & You Can,Too
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