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Toxicity Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and Male BALB/c and am3-C57B46 Mice
John R. Bucher (au)
Sodium dichromate dihydrate is used for electroplating, leather tanning, & textile manufacturing. As a result, sodium dichromate dihydrate & other chromium compounds have been found in drinking water supplies. A series of tests were conducted to determine the effects of sodium dichromate dihydrate on rodents. This report examines short-term (3-month) toxicology tests in rats & 3 strains of mice. These studies were performed to determine doses & the most appropriate test species for future long-term studies of sodium dichromate dihydrate. The study concluded that exposure to sodium dichromate dihydrate caused hyperplasia & ulceration of the stomach in rats & an anemia & lesions of the small intestine in rats & mice. Illustrations.
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