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Toxicity Studies of Dimethylaminopropyl Chloride, Hydrochloride (CAS No. 5407-04-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice
Kamal M. Abdo (au)
Dimethylaminopropyl chloride, hydrochloride is used mainly to make drugs, agricultural chemicals, & photographic chemicals. The Nat. Toxicology Program (NTP) conducted short-term (3-month) tests to determine the effects of dimethylaminopropyl chloride, hydrochloride on rats & mice. This study concluded that exposure to dimethylaminopropyl chloride, hydrochloride for 3 months caused boglet cell hypertrophy of the nose in male rats & increased serum bile acid concentrations in male & female rats. The highest doses of dimethylaminopropyl chloride, hydrochloride that did not result in any observable effects were 50 mg/kg per day for male rats & female mice, 100 to 200 mg/kg per day for female rats, & greater than 100 mg/kg per day for male mice. Ill.
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