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Technical Report on Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CAS No. 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
J.J. Butler (au)
Propargyl alcohol is a commercially available acetylenic primary alcohol. It is used in a variety of chemical manufacturing processes and to protect steel from becoming brittle. The researchers studied propargyl alcohol to determine if it caused cancer in rats or mice. All groups of animals exposed to propargyl alcohol experienced a variety of lesions in the epithelial tissues of the nose, including hyperplase, metaplasia, and inflammation. Adenomas of the respiratory epithelium of the nose were observed in male rats and in male and female mice exposed to propargyl alcohol. The rate of mononuclear cell leukemia was also increased in exposed male rats, and the rate of Harderian gland edenomas was increased in exposed male mice. Illus.
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