Methylene Blue Trihydrate (MBT) has a variety of b

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Technical Report on Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CAS No. 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Methylene Blue Trihydrate (MBT) has a variety of b

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By D. W. Bristol (ed); W. G. Lieuallen (ed)
Year: 2008
Pages: 224
Binding Paperback

Product Code: 1437906613

Description

Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using “Salmonella typhimurium,” “Escherichia coli,” cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. Illustrations.

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