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Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats
K. Barry Delclos (au); Retha R. Newbold (au)
Genistein is a naturally occurring isoflavone that interacts with estrogen receptors & multiple other molecular targets. Human exposure to Genistein is through consumption of soy products, including soy-based infant formula & dietary supplements. A series of short-term studies with Genistein was conducted with two goals: to obtain data necessary to establish dose levels for subsequent multi-generation reproductive & chronic toxicity studies; & to evaluate the effects of Genistein on endpoints outside the reproductive tract. This report focuses on the reproductive & toxicology endpoints. Data obtained in separate evaluations of behavioral, neuroanatomical, neurochemical, & immunological endpoints are also discussed. Illustrations.
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