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Technical Report on Multigenerational Reproductive Toxicology Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study)
D.A. Casciano (ed)
Genistein (GS) is a naturally occurring isoflavone that interacts with estrogen receptors and other molecular targets. Human exposure to GS is through consumption of soy products, incl. soy-based infant formula and dietary supp. Consumption of soy and GS has been assoc. with a variety of beneficial effects in animals and humans, but concerns have also been raised concerning potential adverse effects of GS, particularly with regard to reproductive toxicity and the induction or potentiation of carcinogenesis, due primarily to its weak estrogenic activity. Because of these concerns, GS was selected as one of the compounds to be examined in a protocol utilizing Sprague-Dawley rats to evaluate the effects of multigenerational and long-term exposures to doses of estrogenic agents that produce subtle reproductive tract lesions in developmentally exposed Sprague-Dawley rat pups. Illus.
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