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Technical Report on Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
R.D. Irwin (ed); S.A. Elmore (ed)
Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. The study concludes that exposure to formamide did not cause cancer in male or female rats, but it did produce hemangiosarcomas in the liver of male mice and may have been related to an increase in liver tumors in female mice. Increased incidence of bone marrow hyperplasia in male rats and testicular mineralization in male mice were also associated with formamide exposure. Illus.
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