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Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient p16Ink4a/p19Arf Mice (Gavage Study)
J. K. Dunnick (au)
Benzene is used primarily as a solvent in the chemical & pharmaceutical industries, as a starting material & intermediate in the synthesis of numerous chemicals, & in gasoline. The major U.S. source of benzene is petroleum. Benzene has been previously evaluated in 2-year carcinogenicity studies. In this study, the carcinogenic effects of benzene were studied in the haplo-insufficient p16Ink4a/p19Arf mouse model as part of an ongoing effort to seek improved model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic information relative to understanding an agentís mode of action. Illustrations.
Karluk: The Great Untold Story of Arctic Exploration
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History of the New York Central System
In the Combat Zone: Special Forces Since 1945
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